Bioactive lipids
Natural bioactive lipids constitute a wide variety of substances like polyunsaturated fatty acids, eicosanoids, endocannabinoids, conjugated fatty acids, oxygenated fatty acids, branched fatty acids and more complex lipids like phospholipids. These bioactive fatty acids and lipid derivatives possesses a wide variety of biological effects in the human body and regulate important processes like: inflammation, lipid and glucose metabolism, energy homeostasis, the cells antioxidant defense system and pain modulation.
Research the last 20-30 years has shown that bioactive lipids are potent endogenous ligands for a variety of receptors like the G-coupled protein receptors (GPCR) and nuclear hormone receptors (NHR). The different receptors recognize fatty acids with different chain length, degree of unsaturation and other functionalities present and the biological response depends on the structure of the bioactive lipid.
Biozep can provide a variety of bioactive lipids for research purposes:
Please contact us for quantities and prices.
Research the last 20-30 years has shown that bioactive lipids are potent endogenous ligands for a variety of receptors like the G-coupled protein receptors (GPCR) and nuclear hormone receptors (NHR). The different receptors recognize fatty acids with different chain length, degree of unsaturation and other functionalities present and the biological response depends on the structure of the bioactive lipid.
Biozep can provide a variety of bioactive lipids for research purposes:
Please contact us for quantities and prices.
Oxylipins
Oxylipins are lipophilic signaling molecules derived from the oxidation of polyunsaturated fatty acids (PUFA's). Initial fatty acid oxidation occurs mainly by the enzymatic or chemical formulation of fatty acid hydroperoxides. An array of alternative reactions further converting fatty acid hydroperoxides gives rise to a mulitude of oxylipin classes. In mammals, these oxygenated PUFA mediators play prominent roles in the physiological and pathological regulation of many key biological processes in the cardiovascular, renal, reproductive and other systems including their pivotal contribution to inflammation.
Biozep has a variety of oxylipines in stock and we can provide others on request.
Biozep has a variety of oxylipines in stock and we can provide others on request.
N-acetylethanolamines
Ethanolamides of long-chain fatty acids, collectively referred to as N-acetylethanolamines (NAEs), are present in various mammalian tissues and in plants. The the NAEs have been shown to mediate a wide range of biological effects such as pain regulation, inflammation, modulate appetite and neuroprotection. Receptors involved in their mechanism of action are the cannabinoid receptors (CB1 and CB2), vanilloid receptor, the nuclear receptor peroxisome proliferator-activated receptor a and g and several G-coupled activated receptors such as GPR55 and GPR119.
Biozep has a variety of N-acetylethanolamines in stock and we can provide others on request.
Biozep has a variety of N-acetylethanolamines in stock and we can provide others on request.
Monoacylglycerols
2-arachidonylglycerol (2-AG) is an arachidonic acid containing 2-monoacylglycerol is an endogenous ligand for the cannabinoid receptors, CB1 and CB2, and exhibits a variety of biologocal activities. In vivo administration of 2-arachidonylglycerol has been shown to induce analgesia, immobility, and reduction of spontaneous activity in miceMonoacylglycerols
Biozep has a variety of monoacylglycerols in stock and we can provide others on request.
Biozep has a variety of monoacylglycerols in stock and we can provide others on request.
Polyunsaturated fatty acids
There are four families of polyunsaturated fatty acids (PUFA) derived from the four parent fatty acids; linoleic acid (0mega-6), alpha-linoleic acid (omega-3), oleic acid (omega-9) and palmitoleic acid (omega-7). The two families derived from the omega-6 and the omega-3 polyunsaturated fatty acids are known as the essential fatty acids. They cannot be synthesised by the human body and must be obtained from diet.
Dietary polyunsaturated fatty acids (PUFAs) have documented effects on several physiological processes impacting normal health and chronic diseases, such as the regulation of plasma lipid levels, cardiovascular and immune functions, insulin action, and neuronal development and visual function.
Biozep can deliver a varity of polyunsaturated fatty acids and their ester derivatives from millgram scale up to multigram scale at a competitive price.
Dietary polyunsaturated fatty acids (PUFAs) have documented effects on several physiological processes impacting normal health and chronic diseases, such as the regulation of plasma lipid levels, cardiovascular and immune functions, insulin action, and neuronal development and visual function.
Biozep can deliver a varity of polyunsaturated fatty acids and their ester derivatives from millgram scale up to multigram scale at a competitive price.
3-thia fatty acids
3-thia fatty acids are chemically modified fatty acids with a sulfur atom incorporated in position 3 of a fatty acids. The chemical properties of 3-thia fatty acids are similar to normal fatty acids of similar length, but the metabolism and metabolic effects of differ markedly from these other fatty acids. Because the 3-thia fatty acids are blocked for b-oxidation they are more metabolic stable than similar natural fatty acids. Whereas normal β-oxidation of 3-thia fatty acids does not occur, they are catabolized through ω-oxidation and sulfur oxidation. 3-Thia fatty acids such as tetradecylthioacetic acid (TTA), promote hepatic proliferation of mitochondria and peroxisomes and decrease serum triacylglycerol, cholesterol, and free fatty acid levels in animal models. It is also reported that TTA has antioxidant and antiinflammatory properties,